目的探讨乳酸左氧氟沙星注射液所致不良反应(ADR)的特点,并对安全性进行评价,以促进临床合理用药。方法对2010年3月—2015年8月间于榆林星元医院进行乳酸左氧氟沙星注射后发生ADR的76例患者进行回顾性分析,对患者一般情况、用药情况以及不良反应表现进行考察。结果 76例ADR病例当中,男性占51.32%,女性占48.68%。患者年龄以61~80岁所占构成比最大;原患疾病以呼吸系统感染所占构成比最大,占全部病例的47.37%;用药剂量以每次300 mg的患者所占构成比最大,为51.3%;联合用药占21.05%,以头孢菌素类联用最为多见;给药后24 h内发生ADR病例所占构成比最大;共出现51例单一器官受累及33例多重器官受累,以消化系统和皮肤受累所占构成比最高;好转33例,痊愈43例。结论乳酸左氧氟沙星在临床各种疾病的治疗中均可能出现不良反应,在使用该药物进行治疗时,必须进行合理应用与不良反应监测,以保障患者用药安全。 Objective To investigate the characteristics of adverse reactions caused by levofloxacin lactate injection (ADR) and to evaluate the safety so as to promote the clinical rational use of drugs. Methods A retrospective analysis was performed on 76 ADR patients who were injected with levofloxacin lactate lactate in Yulin Xingyuan Hospital from March 2010 to August 2015. The general situation, medication status and adverse reactions of the patients were investigated. Results Among the 76 ADR cases, 51.32% were male and 48.68% were female. The age of patients accounted for the largest proportion of 61 to 80 years old; the original disease accounted for the largest proportion of respiratory infections, accounting for 47.37% of all cases; the dosage of 300 mg per patient accounted for the largest proportion of 51.3 %; Combined treatment accounted for 21.05%, the most common cephalosporin combination; occurred within 24 h after administration of ADR cases accounted for the largest proportion; a total of 51 cases of single organ involvement and 33 cases of multiple organ involvement, to digest System and skin involvement accounted for the highest proportion; improvement in 33 cases, 43 cases of recovery. Conclusion Levofloxacin lactate may have adverse reactions in the treatment of various clinical diseases. When using this drug for treatment, it is necessary to conduct rational application and adverse reaction monitoring to ensure the safety of patients.