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目的探究来曲唑促排卵的功效。方法对2011年1月至2013年3月在南京大学医学院附属鼓楼医院进行促排卵指导同房治疗的患者中随机抽取180例不孕症患者,进行分组,分为HMG组、CC组和来曲唑组,每组为60例患者。HMG组仅给予患者HMG(人绝经后促性腺激素),CC(枸橼酸氯米芬)组给予患者CC+HMG,来曲唑组给予患者来曲唑+HMG。对三组患者子宫内膜厚度、成熟卵泡数、雌二醇水平、妊娠率。结果来曲唑组患者在度雌二醇水平较HMG组、CC组具有显著差异(P<0.05)说明其具有统计学意义。来曲唑组患者在度子宫内膜厚度上与HMG组无显著差异(P>0.05),与CC组具有显著差异(P<0.05)说明其具有统计学意义。来曲唑组患者在成熟卵泡数及妊娠率较HMG组、CC组无显著差异(P>0.05)。结论来曲唑可以有效促进不孕症患者的排卵,同时可以减少抗雌激素样作用的不良反应。临床值得推广。
Objective To investigate the efficacy of letrozole in promoting ovulation. Methods A total of 180 infertile patients were randomly selected from patients who were ovulation-guided ovulation induction therapy at Drum Tower Hospital affiliated to Nanjing University Medical College from January 2011 to March 2013. The patients were divided into HMG group, CC group and Ligong Azole group, 60 patients in each group. Patients in HMG group were given only HMG (human postmenopausal gonadotropin), CC (clomiphene citrate) group was given CC + HMG, and letrozole was given to letrozole + HMG. The endometrial thickness, the number of mature follicles, the level of estradiol and the pregnancy rate of the three groups of patients. Results The letrozole group had a significant difference in degree of estradiol compared with HMG group and CC group (P <0.05). There was no significant difference between the letrozole group and the HMG group in endometrial thickness (P> 0.05), which was significantly different from that in the CC group (P <0.05). There was no significant difference in the number of mature follicles and pregnancy between the letrozole group and HMG group and CC group (P> 0.05). Conclusion Letrozole can effectively promote ovulation in patients with infertility, and can reduce the adverse reaction of anti-estrogen-like effect. Clinical worth promoting.