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镁的非肠道用药在心血管和神经性疾病方面可能有治疗作用。较大的二次Leice-ster静注硫酸镁干预试验(LIMIT-2)发现用硫酸镁(MgSO_4)治疗的心肌梗塞后的病人,改善了早期和晚期的死亡率,提示镁可能是细胞保护剂。镁通过内皮细胞前列腺环素释放的刺激作用而引起血管扩张。Mg~(2+)离子阻滞
Parenteral magnesium may have therapeutic effects on cardiovascular and neurological diseases. Larger secondary Leice-ster magnesium sulfate intervention trials (LIMIT-2) found that patients after myocardial infarction treated with magnesium sulfate (MgSO 4) improved early and late mortality, suggesting that magnesium may be a cytoprotective agent . Magnesium causes vasodilatation through stimulation of prostacyclin release by endothelial cells. Mg 2+ ion block