目的　评价肺耐药相关蛋白基因（ｌｒｐ） 、多药耐药相关蛋白基因（ｍｒｐ） 和多药耐药基因（ｍｄｒ１）及其编码的ｐ１７０ 蛋白表达与急性白血病患者多药耐药（ＭＤＲ）的关系。方法　将８５ 例急性白血病患者分为初治敏感（Ａ） 、完全缓解（Ｂ）和复发难治（Ｃ） 组，用逆转录聚合酶链反应（ＲＴＰＣＲ） 法检测患者骨髓单个核细胞中ｌｒｐ 、ｍｒｐ 和ｍｄｒ１ 的ｍＲＮＡ 表达，同时用免疫细胞化学方法检测ｐ１７０ 表达。结果　（１）ｌｒｐ 基因表达在急性非淋巴细胞白血病（ＡＮＬＬ） Ａ、Ｂ、Ｃ 三组阳性表达分别为１１．１１％ 、９－０９％ 、３６．３６％ ； 在急性淋巴细胞白血病（ＡＬＬ）Ａ、Ｂ、Ｃ三组阳性表达分别为０％ 、２０ ．００％ 、４６ ．６７％ 。（２）ｍｒｐ 在ＡＮＬＬ中Ａ、Ｂ、Ｃ三组阳性表达分别为４４ ．４４％ 、９．０９％ 、５９．０９％ ； 在ＡＬＬ中Ａ、Ｂ、Ｃ三组阳性表达分别为２８．５７％ 、２０．００％ 、５３．３３％ ；（３）ｍｄｒ１ 在ＡＮＬＬ 中Ａ、Ｂ、Ｃ 三组阳性表达分别为０％ 、４－５４％ 、５９．０９ ％ ， 在ＡＬＬＡ、Ｂ、Ｃ三组阳性表达分别为０％ 、０％ 、３３．３３％ ；（４）ｐ１７０ 在ＡＮＬＬ复发难治组表达（９－ Objective To evaluate the expression of lung resistance-associated protein gene (lrp), multidrug resistance-associated protein gene (mrp), multidrug resistance gene (mdr1) and its encoded p170 protein and multidrug resistance in acute leukemia patients (MDR )Relationship. Methods Eighty-five patients with acute leukemia were divided into primary treatment-sensitive (A), complete remission (B), and relapse-refractory (C) groups. The bone marrow mononuclear cells were detected by reverse transcriptase polymerase chain reaction (RT-PCR). The expression of lrp, mrp, and mdr-1 mRNA was also detected, and p170 expression was detected by immunocytochemistry. Results (1) The expression of lrp gene in acute nonlymphocytic leukemia (ANLL) A, B, and C groups was 11.11%, 9-09%, and 36.36%, respectively; in acute lymphoblastic leukemia (ALL) The positive expression of A, B and C groups was 0% and 20. 00%, 46. 67%. (2) The positive expression of mrp in ANL in groups A, B and C was 44. 44%, 9.09%, 59.09%; The positive expression of A, B, and C in ALL was 28.57%, 20.00%, and 53.33%, respectively; (3) mdr1 in ANLL The positive expression of A, B, and C in the three groups was 0%, 4-54%, and 59.09%, respectively, and the positive expression in ALLA, B, and C groups was 0%, 0%, and 33.33%, respectively; ) p170 expression in relapsed and refractory group of ANLL (9-