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文献报道血浆苯巴比妥治疗浓度的范围很大,由43至302μmol/升(10～70微克/毫升),作者对13例未经治疗过的癫痫患者应用苯巴比妥、以试图决定这类癫痫患者的最佳治疗量与血浆浓度.这13例中5例为儿童(全为女性),8例成人(男6、女2,17～70岁).9例为全身性强直—阵挛发作,2侧为复杂部份性发作,1例并有简单和复杂的部份性发作,1例为复杂部份性发作和继发性全身性发作.病程为3个月到7年.在治疗前至少有二次发作.
It has been reported in the literature that there is a wide range of plasma phenobarbital concentrations ranging from 43 to 302 μmol / L (10 to 70 μg / mL) and the authors applied phenobarbital to 13 untreated epilepsy patients in an attempt to determine this Among the 13 cases, 5 were children (all women), 8 were adults (6 males, 2 females, 17 to 70 years old), and 9 were generalized patients with ankylosing spondylitis Two cases were complicated seizures, one with simple and complex partial seizures, and one case with complicated partial seizures and secondary generalized seizures.The course of disease ranged from 3 months to 7 years. At least two seizures before treatment.