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目的观察联合应用丙种球蛋白和炎琥宁对小儿手足口病的疗效。方法将96例确诊的手足口病患儿随机分成对照组和观察组,对照组44例,采取单纯炎琥宁治疗,观察组52例采用丙种球蛋白联合炎琥宁治疗,比较2组疗效。结果对照组和观察组的总有效率分别为84.10%和98.08%,2组比较差异有统计学意义(P<0.01)。观察组退热时间、疱疹消退时间及平均住院时间均低于对照组(均P<0.01)。结论丙种球蛋白联合炎琥宁治疗手足口病的疗效确切,具有一定的临床意义。
Objective To observe the effect of combined use of gamma globulin and midazolam on children hand-foot-mouth disease. Methods Ninety-six children with HFMD were randomly divided into control group and observation group. Forty-four patients in the control group were treated with memantine alone. Fifty-two patients in the observation group were treated with gamma globulin and Yan Hu Ning. The curative effect was compared between the two groups. Results The total effective rates of the control group and the observation group were 84.10% and 98.08%, respectively. There was significant difference between the two groups (P <0.01). The observation group antipyretic time, herpes subsidence time and the average length of stay were lower than the control group (P <0.01). Conclusion Gamma globulin combined with mesylate treatment of hand, foot and mouth disease is effective and has certain clinical significance.