目前治疗深部真菌病的高效低毒药物不多，仍选用延用了近４０年的二性霉素Ｂ，但其毒性较大，应用受限。５氟胞嘧啶（５ＦＣ）抗菌谱窄，易产生耐药，一般不单独使用。６０年代末合成克霉唑和咪康唑。８０年代后，酮康唑、氟康唑等新的抗真菌药相继问世，其中氟康唑是目前临床应用最广，效果最好的抗真菌药物。 At present, the treatment of deep fungal disease is not efficient and low toxicity drugs, still use the extension of nearly 40 years of amphotericin B, but its toxicity is limited, the application is limited. 5  flucytosine (5  FC) narrow antibacterial spectrum, easy to produce resistance, generally not alone. In the late 1960s, clotrimazole and miconazole were synthesized. Since the 1980s, new antifungal drugs such as ketoconazole and fluconazole have come out one after another. Fluconazole is currently the most widely used and effective antifungal drug.