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采用可逆-加成-断裂链转移自由基聚合(RAFT)技术合成了两亲性嵌段共聚物聚苯乙烯-b-聚甲基丙烯酸聚乙二醇单甲醚-b-聚苯乙烯(PSt-b-POEOMA-b-PSt),通过FT-IR、1 HNMR、GPC确定共聚物的结构。将三个具有不同嵌段比的共聚物在水溶液中自组装,通过透射电子显微镜(TEM)观察得到的胶束的形貌,发现随着亲水性嵌段的比例减小,胶束的直径略微减小。通过透析方法,以共聚物作为载体,负载维生素E,TEM观察载药胶束的形貌,仍然为核-壳状的球形胶束。差示扫描量热仪(DSC)测试共聚物载药胶束前后的热性能,发现药物分子在载入内核的过程中,聚苯乙烯的玻璃化转变温度(Tg)有所降低。通过紫外(UV)分析计算得出共聚物的药物负载量(DLC)为70%～80%。
The amphiphilic block copolymer polystyrene-b-poly (ethylene glycol monomethylether) -b-polystyrene (PSt) was synthesized by reversible addition-fragmentation chain transfer radical polymerization (RAFT) -b-POEOMA-b-PSt), the structure of the copolymer was confirmed by FT-IR, 1 HNMR, GPC. Three copolymers with different block ratios were self-assembled in aqueous solution. The morphologies of micelles obtained were observed by transmission electron microscopy (TEM) and found that as the proportion of hydrophilic blocks decreased, the diameter of the micelles Slightly reduced. Through the dialysis method, the copolymer was used as the carrier, vitamin E was loaded and TEM was used to observe the morphologies of the drug-loaded micelles, and the core-shell spherical micelles remained. Differential scanning calorimetry (DSC) tests the thermal properties of the copolymer micelles before and after loading, and found that the glass transition temperature (Tg) of the polystyrene decreases as the drug molecules are loaded into the core. The copolymer’s drug loading (DLC) was calculated from 70% to 80% by UV analysis.