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本文报道24例急性心肌梗塞患者发病24小时内血 TXB_2,6-K-PGF_(1α),PRA 和ATⅡ的水平。与正常对照组比较,心梗组血 TXB_2,6-K-PGF_(1α)及 T/P 比值显著增加(P<0.01),提示 TXA_2,PGI_2失衡的致病作用。而 T/P 比值改变可作为防治本病的参考指标。本文还观察到,心梗急性期血清 CPK 水平与血 TXB_2,T/P 比值无相关性(P>0.05),而与6-K-PGF_(1α)呈正相关(P<0.025)。另外,同时测定 PRA,AT Ⅱ表明,在排除开搏通影响后(本文心梗患者中有13例服用开搏通,其血 PRA 较对照组显著升高,P<0.01,ATⅡ降低,P<0.025。11例未服用者血 PRA,ATⅡ均较对照组显著升高,P<0.01),提示心梗急性期肾素——血管紧张素系统活性增加。
This article reports the levels of TXB_2, 6-K-PGF_ (1α), PRA and ATⅡ in 24 patients with acute myocardial infarction within 24 hours after onset. Compared with the normal control group, the TXB_2, 6-K-PGF_ (1α) and T / P ratio in myocardial infarction group increased significantly (P <0.01), suggesting the pathogenic effects of TXA_2 and PGI_2 imbalance. The T / P ratio change can be used as a reference indicator for the prevention and treatment of this disease. This study also observed that there was no correlation between serum CPK levels and the levels of TXB_2 and T / P in acute myocardial infarction (P> 0.05), but positively correlated with 6-K-PGF_ (1α) (P <0.025). In addition, the simultaneous determination of PRA, AT Ⅱ showed that in the exclusion of Civet (after myocardial infarction in 13 cases of patients taking Caifei, blood PRA was significantly higher than the control group, P <0.01, AT Ⅱ decreased, P < 0.025.11 The blood levels of PRA and ATⅡ in non-users were significantly higher than those in control group (P <0.01), suggesting that the activity of renin-angiotensin system was increased in acute stage of myocardial infarction.