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目的:探讨不同剂量胍丁胺对戊四氮诱导的慢性癫癎大鼠模型的保护作用及对海马区星形胶质细胞表达的影响。方法:连续28 d腹腔注射戊四氮35 mg.kg-1建立大鼠慢性癫癎模型。不同剂量胍丁胺(20、40、80 mg.kg-1)进行干预。观察大鼠癫癎发作行为学及海马的形态学变化,检测海马星形胶质细胞的表达。结果:胍丁胺40、80 mg.kg-1可降低癫癎发作的日均等级评分,减少海马神经元丢失及星形胶质细胞增生。结论:胍丁胺40、80 mg.kg-1可抑制慢性癫癎大鼠发作,降低惊厥发作后海马星形胶质细胞的异常增生及神经元损伤。
Objective: To investigate the protective effects of agmatine on pentylenetetrazole-induced chronic epileptic rat model and its effect on the expression of astrocytes in hippocampus. Methods: Chronic epileptic model of rats was established by intraperitoneal injection of pentylenetetrazole 35 mg.kg-1 for 28 days. Different doses of agmatine (20,40,80 mg.kg-1) intervention. The behavior of epileptic seizures and the morphological changes of hippocampus were observed in rats, and the hippocampal astrocytes were detected. Results: Agmatine 40 and 80 mg.kg-1 decreased the average daily score of epileptic seizures and decreased the loss of hippocampal neurons and the proliferation of astrocytes. Conclusion: Agmatine 40 and 80 mg.kg-1 can inhibit the onset of chronic epileptic rats and reduce the abnormal proliferation and neuron damage of hippocampal astrocytes after seizures.