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目的:了解我院药物不良反应(ADR)的相关因素,为促进临床合理用药提供依据。方法:对我院2008年全年上报695例ADR报表中分别从患者的年龄、性别、有无过敏史、报告人身份以及发生不良反应的药品剂型、种类、给药途径等方面进行统计分析。结果:注射给药ADR发生率为90.07%,抗感染药物ADR发生率最高为58.85%,其次是中药类为18.56%,两联用药占61%,一般的不良反应81%,新的一般不良反应18.56%,新的严重的不良反应0.28%。主要不良反应类型为皮肤变态反应,消化系统反应次之。结论:重视药品不良反应,掌握、了解药品不良反应的特点,对合理用药,减少药品不良反应的发生将起到积极作用。
Objective: To understand the related factors of adverse drug reaction (ADR) in our hospital and provide basis for promoting clinical rational drug use. Methods: A total of 695 cases of ADR reported in our hospital in 2008 were statistically analyzed in terms of patient’s age, gender, history of allergy, reporter’s identity, adverse drug reactions, type of drug and route of administration. Results: The incidence of ADR was 90.07%, the highest incidence of ADR was 58.85%, followed by 18.56% for traditional Chinese medicine, 61% for combination therapy, 81% for common adverse reactions, and new general adverse reactions 18.56%, new serious adverse reaction 0.28%. The main type of adverse reaction is skin allergy, followed by the digestive system. Conclusion: Paying attention to adverse drug reactions, mastering and understanding the characteristics of adverse drug reactions will play a positive role in rational use of drugs and reduction of adverse drug reactions.