美《科学》杂志第204卷第4397期(1979年6月8日)第1089页报道:根据遗传学资料分析了30名年青妇女有家族性乳癌的危险性者,收集其整个月经周期间每天的尿标本,并与年龄、体重和生育史可以相配的30名对照妇女的尿标本作比较。用葡萄糖醛酸酶水解法提取尿中的类固醇,应用放射免疫测定法对糖皮质激素、雄激素、雌激素及其代谢产物进行测定。两组的雌酮和雌二醇之间发现有很显著的差别。有高度乳癌危险的妇女与对照组相比,雌酮及雌二醇均呈现低值。在有家族性乳癌危 Science, Vol. 204, No. 4397, June 8, 1979, p. 1089: According to genetic data, 30 young women at risk of familial breast cancer were collected and collected daily for the entire menstrual cycle Urine specimens from 30 control women who were matched for age, weight, and reproductive history were compared. Urinary steroids were extracted by glucuronidase hydrolysis, and glucocorticoid, androgen, estrogen and their metabolites were determined by radioimmunoassay. There was a significant difference between estrone and estradiol in both groups. Estrone and estradiol showed low values ​​in women at high risk of breast cancer compared with controls. In familial breast cancer risk