论文部分内容阅读
观察大鼠胆管梗阻后内皮素在肝脏组织及血液中的分泌状况及甘胆酸的变化，探讨内皮素与甘胆酸之间的关系，了解内皮素在试验动物肝损伤中的作用。方法：用放射免疫法观察大鼠胆管梗阻后５、１０、１５、２０、２５ｄ时血及肝组织中内皮素含量，组织病理切片观察肝脏的病理改变。结果内皮素含量随梗阻性黄疸后时间延长而递增，与甘胆酸升高水平呈正相关（Ｐ＜０．０１）；说明内皮素可能是参与梗阻性黄疸致肝损伤的重要因素之一
To observe the secretion of endothelin in the liver tissue and blood and the changes of glycocholic acid after bile duct obstruction in rats, and to explore the relationship between endothelin and glycocholic acid and to understand the role of endothelin in liver injury in experimental animals. Methods: The levels of endothelin in blood and liver tissues were observed by radioimmunoassay at 5, 10, 15, 20, 25 days after biliary obstruction. The pathological changes of liver were observed by histopathological sections. Results Endothelin levels increased with time after obstructive jaundice and was positively correlated with elevated levels of glycocholate (P <0.01), indicating that endothelin may be one of the important factors involved in liver injury caused by obstructive jaundice