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美《科学》杂志第207卷第4427期(1980年)第193页刊载美国斯坦福大学生理学系及加州霍普金斯海洋站弗尔曼(F.A.Fuhrman)等的一篇报告说,最近曾报告过加利福尼亚海湾产的一种裸鳃亚目(dorid nudibranchs)含有数种药理活性物质,其中一种物质是从An-isodoris nobilis消化腺的水提取物中分离的,名为doridosine,是一种新的甲替嘌呤核糖苷(N-methylpurine riboside)。 Anisodoris nobilis是在加州蒙特利湾搜集的。在试管中,doridosine减低豚鼠心房搏动的收缩率。浓度为3.75毫克/升时,收缩幅
Science, Vol. 207, No. 4427 (1980), p. 193 According to a report published by the Department of Physiology at Stanford University in the United States and FAFuhrman at California’s Hopkins Marine Station, it has recently been reported One species of dorid nudibranchs produced in the Gulf of California contains several pharmacologically active substances, one of which is isolated from the water extract of the digestive gland of An-isodoris nobilis and is called doridosine, N-methylpurine riboside. Anisodoris nobilis was collected in Monterey Bay, California. In a test tube, doridosine reduces the contraction rate of atrial fibrillation in guinea pigs. Shrinkage amplitude at 3.75 mg / L