目的了解泰安市2008-2013年疑似预防接种异常反应(Adverse Events Following Immunization,AEFI)的发生特征,评价AEFI监测系统的运转情况,分析疫苗的安全性和预防接种服务质量。方法通过泰安市AEFI信息管理系统,收集2008-2013年报告的AEFI个案数据,采用描述流行病学方法进行分析。结果 2008-2013年全市共报告异常反应1 834例,6个县市区均有AEFI数据报告,48h内报告率为96.1%,48h内调查率为87.5%。其中≤1岁占80.67%,男女性别比为1.34∶1。报告的AEFI中,国家免疫规划(National Immunization Program,NIP)疫苗占75.71%,首剂接种疫苗占62.92%,其中80.17%发生在接种后≤1d。一般反应1 744例(95.09%),异常反应62例(3.3%),接种疫苗剂次多且相对集中的0~1岁为主,>1岁组呈下降趋势。发生的季节中第1季度较少,其他季度差别不大。异常反应发生率最高的为百白破疫苗,以发热及局部红肿硬结反应最为常见,共1 416例(77.2%),疫苗反应时间一般为24h以内,经过治疗95%可以治愈。结论泰安市AEFI监测的敏感性有较大提高,但部分县市区48h内报告及时率没有达到100%;AEFI常发生在≤1岁的小年龄儿童,接种NIP疫苗应为监测重点;NIP疫苗不良反应报告发生率均在预期发生范围内,安全性良好。 Objective To understand the occurrence characteristics of suspected AEFI in Tai’an from 2008 to 2013, evaluate the operation of AEFI monitoring system, analyze the safety of vaccines and the quality of vaccination services. Methods AEFI information management system in Tai’an was used to collect the data of AEFI reported in 2008-2013 and the descriptive epidemiological method was used to analyze the data. Results A total of 1 834 cases of abnormal reaction were reported in the city from 2008 to 2013. AEFI data was reported in 6 counties and cities. The report rate was 96.1% in 48 hours and 87.5% in 48 hours. Among them, ≤1 years old accounted for 80.67%, male to female ratio was 1.34:1. Among the reported AEFIs, the National Immunization Program (NIP) vaccine accounted for 75.71%, the first dose of vaccines accounted for 62.92%, of which 80.17% occurred after vaccination ≤ 1d. A total of 1 744 cases (95.09%) were common reactions, 62 cases (3.3%) were abnormal reactions, and the number of vaccinated agents was more and the relative concentration was 0 to 1 year old. The incidence of> 1 year old group was on the decline. Less seasonal season occurred in the first quarter, the other quarter is not much difference. Abnormal reaction rate was the highest incidence of diphtheriae vaccine, fever and local inflamed induration reaction is the most common, a total of 1 416 cases (77.2%), the vaccine response time is generally less than 24h, 95% after treatment can be cured. Conclusion The sensitivity of AEFI monitoring in Tai’an has been greatly improved, but the reporting rate in some counties and cities has not reached 100% in 48 hours. AEFI often occurs in children younger than 1 year old. NIP vaccination should be the focus of surveillance. NIP vaccine The incidence of adverse reactions were within expected range, good safety.