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目的:探讨孕妇胎盘缺氧诱导因子(HIF-1α)表达变化与子痫前期发病的关系。方法:以“HIF-1α、子痫前期(preeclampsia)”为检索词检索Medline、EMBase、PubMed数据库、中国生物医学文献数据库、万方数据库,收集HIF-1α与子痫前期发病关系的病例对照研究,筛选、评价文献并提取数据进行Meta分析。结果:共纳入6项研究,主要从病例组与对照组方法的选择、病例组与对照组的可比性、接触暴露评估方法 3个方面对文献进行评价。Meta分析结果表明,子痫前期组胎盘组织中HIF-1α表达水平高于正常妊娠组[OR=5.65,95%CI(3.42,9.33)]。结论:孕期HIF-1α的高表达与子痫前期的发病有关。
Objective: To investigate the relationship between placental hypoxia inducible factor (HIF-1α) expression and preeclampsia in pregnant women. METHODS: Medline, EMBase, PubMed database, China Biomedical Literature Database and Wanfang database were searched using the terms “HIF-1α and preeclampsia” as the search terms. The relationship between HIF-1α and preeclampsia was collected Control study, screening, evaluation of literature and data extraction Meta analysis. Results: A total of six studies were included, and the literature was evaluated mainly from the selection of methods in case group and control group, comparability of case group and control group, and exposure exposure assessment method. Meta-analysis showed that the expression of HIF-1α in placenta of preeclampsia group was higher than that in normal pregnancy group [OR = 5.65,95% CI (3.42,9.33)]. Conclusion: The high expression of HIF-1α during pregnancy is related to the pathogenesis of preeclampsia.