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本文通过对36例十二指肠球部溃疡（DU）患者治疗前后，多种胃肠激素及胃电进行检测分析，观察溃疡病治疗前后及HP清除后的胃肠激素变化与胃动力的关系，进一步探讨消化性溃疡的发病机制。36例DU患者4周愈合率86．1％，治疗前的GAS、SS、EGF、MOT分别为117．72±6．4pg／ml、4．37±1．1pg／ml、0．618±0．25ng／ml和378．5±19．1ng／ml。治疗后则为92．6±4．2pg／ml、8．26±1.2pg／ml、1．12±0．18ng／ml和432．5±17.2ng／ml，前后有显著性差异；DU治疗后HP阳性转阴者与未转阴者之间有差异。HP根除后，3种激素恢复至接近对照组，MOT水平仍高，与胃电活动相一致。从中看出DU的发病与HP感染及各种胃肠激素分泌异常和调节失常有关，也与胃动力改变有关。
In this paper, 36 cases of duodenal ulcer (DU) before and after treatment in patients with a variety of gastrointestinal hormones and gastric electrical tests were analyzed to observe the changes of gastric motility before and after treatment of peptic ulcer patients with HP and the changes of gastrointestinal hormones , To further explore the pathogenesis of peptic ulcer. 36 cases of DU patients with 4 weeks healing rate of 86.1%, before treatment GAS, SS, EGF, MOT were 117.72 ± 6.4pg / ml, 4.37 ± 1.1pg / ml, 0.618 ± 0 .25 ng / ml and 378.5 ± 19.1 ng / ml. After treatment, they were 92.6 ± 4.2pg / ml, 8.26 ± 1.2pg / ml, 1.12 ± 0.18ng / ml and 432.5 ± 17.2ng / ml respectively, with significant difference before and after treatment; DU treatment After the HP positive negative and non-negative differences between. After the eradication of HP, the three hormones returned to the control group, the level of MOT was still high, consistent with the gastric activity. It can be seen from the pathogenesis of DU and HP infection and various abnormal secretion of gastrointestinal hormones and regulatory disorders, but also with changes in gastric motility.