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[目的]探讨血清高敏感C-反应蛋白(hs-CRP)水平在预测冠状动脉事件发生中的作用。[方法]应用速率散射免疫比浊法对60例急性冠状动脉综合征(ACS)患者(ACS组)与60例体检健康的对照者(对照组)进行血清hs-CRP测定;根据hs-CRP水平将ACS组分为3个亚组,A组22例,血清hs-CRP(48.55±13.04)mg/L;B组20例,血清hs-CRP(44.15±11.26)mg/L;C组18例,血清hs-CRP(36.85±10.19)mg/L。随访冠状动脉事件2年。[结果]①ACS组血清hs-CRP水平(43.57±12.36)mg/L显著高于对照组(8.13±2.02)mg/L;②A、B、C3个亚组冠状动脉事件发生例数分别为8例、4例、1例,冠状动脉事件发生率分别为36.36%、20.0%、5.56%,冠状动脉事件发生率3个亚组之间有统计学差异(P﹤0.05)。[结论]ACS患者血清hs-CRP水平显著增高与冠状动脉事件发生有明显的关系,hs-CRP水平可作为ACS患者未来冠状动脉事件发生的危险信号。
[Objective] To investigate the role of serum high sensitive C-reactive protein (hs-CRP) in predicting the occurrence of coronary events. [Method] The serum hs-CRP levels were measured in 60 patients with acute coronary syndrome (ACS) and 60 healthy controls (control group) by rate-scattering immunoturbidimetry. According to hs-CRP level Serum hs-CRP (48.55 ± 13.04) mg / L, 20 cases in group B, serum hs-CRP (44.15 ± 11.26) mg / L and 18 cases in group C were divided into three subgroups: A group , Serum hs-CRP (36.85 ± 10.19) mg / L. Follow-up of coronary events for 2 years. [Results] ① The serum hs-CRP level in ACS group (43.57 ± 12.36) mg / L was significantly higher than that in control group (8.13 ± 2.02) mg / L; ② The incidences of coronary events in groups A, B and C3 were 8 , 4 cases and 1 case. The incidence of coronary events were 36.36%, 20.0% and 5.56%, respectively. There was a significant difference between the three subgroups of coronary events (P <0.05). [Conclusion] There is a clear relationship between serum hs-CRP levels and coronary events in patients with ACS. The level of hs-CRP may be used as a risk signal for future coronary events in patients with ACS.