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促癌基因bcl-2是众所周知的凋亡抑制因子,在正常人的复层鳞状上皮中,它的表达局限在基底细胞层。本实验旨在研究bcl-2蛋白在口腔角朊细胞分化过程中的作用。 正常情况下,SCC-25在体外经过鳞状细胞的分化,而且表达特殊的分化标志为角蛋白10/11和胞膜素。研究方法是将bcl-2通过PBC140载体转染到SCC-
The oncogene bcl-2 is a well-known inhibitor of apoptosis and its expression is confined to the basal cell layer in normal human stratified squamous epithelium. The aim of this study was to investigate the role of bcl-2 in oral keratinocyte differentiation. Normally, SCC-25 undergoes squamous cell differentiation in vitro and expresses specific differentiation markers as keratin 10/11 and macrophage. The research method is to bcl-2 by PBC140 vector transfected into SCC-