论文部分内容阅读
测定了１１４例糖尿病患者血、尿β＿２－微球蛋白（β＿２－ＭＧ）。结果发现，糖尿病患者血、尿β＿２－ＭＧ明显高于正常对照组（Ｐ＜０．０１）；糖尿病患者血、尿β＿２－ＭＧ随病程延长而增加，尿β＿２－ＭＧ的增加尤为显著。血、尿β＿２－ＭＧ在非胰岛素依赖性糖尿病（ＮＩＤＤＭ）和胰岛素依赖性糖尿病（ＩＤＤＭ）之间无显著性差异（Ｐ＞０．０５）。糖尿病患者的尿β＿２－ＭＧ随血β＿２－ＭＧ升高而升高，并随病程的延长而增加。提示病程越长，肾功能损伤越重。故β＿２－ＭＧ测定对早期发现糖尿病性肾病及其预防和治疗有重要意义。
Blood and urine β_2-microglobulin (β_2-MG) were measured in 114 patients with diabetes mellitus. The results showed that serum and urinary β_2-MG of diabetic patients were significantly higher than those of normal control group (P <0.01). The blood and urine β_2-MG of diabetic patients increased with the prolongation of duration, especially the increase of urinary β_2-MG. Blood and urine β_2-MG showed no significant difference between non-insulin-dependent diabetes mellitus (NIDDM) and insulin-dependent diabetes mellitus (IDDM) (P> 0.05). The urinary β_2-MG of diabetic patients increased with the increase of β_2-MG, and increased with the prolongation of the course of disease. Tip longer duration, heavier renal damage. So β_2-MG determination of early detection of diabetic nephropathy and its prevention and treatment of great significance.