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评价了基于甲基丙烯酸(MAA)的离子交换树脂(IERs)对阿奇霉素(AZI)的掩味作用,以及由壳聚糖和羧基化琼脂糖钠形成的半互穿聚合物网络(IPN)颗粒对药物的缓释作用。首先采用悬浮聚合法制备MAA-IERs,再制备不同药物/树脂比(1∶1、1∶2和1∶4)的树脂复合物,并用差示扫描量热(DSC)、傅里叶变换红外光谱(FTIR)、粉末X射线衍射(PXRD)进行表征,评价其体内外掩味效果以及在胃部p H条件下的体外释放情况。进而采用生物聚合物包埋树脂复合物,用枸橼酸钠进行离子化交联,再用戊二醛交联,得到对AZI具有缓释效果的IPN颗粒。结果显示,1∶4的树脂复合物掩味
The taste masking of azithromycin (AZI) by methacrylic acid (MAA) -based ion exchange resins (IERs) as well as the semi-interpenetrating polymer network (IPN) particle pairs formed from chitosan and carboxylated agarose sodium Slow release of drugs. Firstly, MAA-IERs were prepared by suspension polymerization and then resin composites with different drug / resin ratios (1: 1, 1: 2 and 1: 4) were prepared and characterized by differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) and powder X-ray diffraction (PXRD) were used to characterize the in vitro and in vivo masking effects and in vitro release under the gastric p H condition. Further, the biopolymer is used to embed the resin composite, ionized and cross-linked with sodium citrate, and then crosslinked with glutaraldehyde to obtain IPN particles with sustained release effect on AZI. The results show that the 1: 4 resinous compound masks the taste