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目的:评价流感疫苗对流感所致死亡的预防作用。 研究设计:前瞻性队列研究,随访社区确诊并计入国家流感统计周报的人群。 研究背景:初级保健。 参与者:24535名来自英国73个全科医师医疗服务站的年龄在75岁以上的病人。 主要结局测定指标:死亡。 结果:在未进行疫苗接种的队列成员中,每日全因死亡率与人群流感流行指数密切相关(在流感流行第90个百分位点,死亡率比值为1.16,95％可信区间为1.04-1.29),
Objective: To evaluate the preventive effect of influenza vaccine on flu-induced death. Study Design: Prospective cohort study, follow-up community diagnosed and enrolled in the National Influenza Weekly Statistics Population. Research Background: Primary Care. Participants: 24,535 patients aged 75 and over from 73 general practitioner medical service stations in the United Kingdom. The main outcome measures: death. Results: Among unvaccinated cohorts, all-cause mortality was closely related to the population flu prevalence index (mortality rate ratio was 1.16 at the 90th percentile of the flu epidemic, 95% confidence interval was 1.04 -1.29),