论文部分内容阅读
自从1937年 Meyer 氏等由“扩散因子”中分离出透明质酸酶(Hyaluronidare),1940年经 Chain及 Guthie 氏阐明其作用后,20年来在临床上应用日见广泛。我院自1960年4月超开始应用该剂,体会到其效力甚佳,优点亦多,故加以介绍讨论。一、药理性质:透明质酸酶为一种粘液溶解酶,可吸水解透明酸,去除其聚叠性,而透明质酸又是细胞间粘合质之主要成份,因此局部注入后有助药液的迅速瀰散,扩大浸润面积.缩短吸收时间。加于麻醉剂中应用,则有减少用药量,扩大麻醉区域,提高药液穿透力及短缩濳伏期的效力。但由于吸收迅速,作用持续时间也相对缩短。因其不能穿越筋膜,故无吸收后的全身性药理作用。然而如果大量静脉內注射,恐将引起广泛血管壁渗透力增加,甚至发生弥漫性出血的严重全身副作用。此药市售品通常由家畜睪丸中提出,系白色粉末状或细碎膜片状,易溶于水,不溶于酒精或醚类。
Since 1937 Hyaluronidare was isolated from “diffusion factor” by Meyer et al., And was clarified by Chain and Guthie’s in 1940, it has been widely used in clinic for 20 years. Our hospital since April 1960 Super began to use the agent, experience its effectiveness is very good, the advantages are more, it is introduced to discuss. First, the pharmacological properties: hyaluronidase is a mucolytic enzyme, can absorb transparent acid hydrolysis, to remove its overlap, and hyaluronic acid is the main component of the intercellular adhesion substance, so the local injection of aids Rapid dispersion of liquid to expand the infiltration area. Shorten the absorption time. Add to anesthesia in the application, then there is to reduce the dosage, to expand the anesthesia area, improve liquid penetration and shortened period of efficacy. However, due to rapid absorption, the duration of the effect is also relatively shortened. Because it can not cross the fascia, it has no systemic pharmacological effects after absorption. However, a large amount of intravenous injection may cause extensive systemic wall penetration and serious systemic side effects such as diffuse hemorrhage. The drug is usually marketed by livestock pills, which are white powder or fine crushed tablets, soluble in water and insoluble in alcohol or ethers.