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采用造血祖细胞培养技术研究了健康老年人骨髓多向祖细胞的增殖能力和自我更新能力。发现健康老年人骨髓多向祖细胞（ＣＦＵ－ＧＥＭＭ）的集落数为每１×１０５细胞１１．９９±４．６８，明显低于健康成年人；骨髓细胞经白细胞介素－３孵育后进行培养，健康老年人ＣＦＵ－ＧＥＭＭ的集落数为每１×１０￣５细胞２．１８±１．０２，亦明显低于健康成年人的。表明健康老年人骨髓多向祖细胞的增殖能力和自我更新能力减低。
The hematopoietic progenitor cell culture technique was used to study the proliferative ability and self-renewal ability of bone marrow multipotent progenitor cells from healthy elders. The number of CFU-GEMM colonies in healthy elderly was 11.99 ± 4.68 per 1 × 105 cells, which was significantly lower than that in healthy adults. The bone marrow cells were incubated with interleukin-3 The number of CFU-GEMM in healthy elderly population was 2.18 ± 1.02 per 1 × 105 cells, which was also significantly lower than that in healthy adults. Decreased proliferation and self-renewal capacity of bone marrow multi-committed progenitor cells in healthy elderly.