目的探讨视网膜母细胞瘤的临床特点及病理特征。方法回顾分析我院1966年1月～2007年9月41年136例视网膜母细胞瘤病例。结果临床特点:(1)发病年龄多见于3岁以下的患儿;(2)多数患儿未能在早期视力减退时就诊;(3)以单眼发病多见。病理特征:(1)肿瘤多见于未分化型;(2)视神经无转移者多见。结论加强科普宣传,提倡优生优育。争取早期发现,早期行局部保守治疗,以保存患者的患眼和部分视力。 Objective To investigate the clinical features and pathological features of retinoblastoma. Methods A retrospective analysis of our hospital from January 1966 to September 2007 41 cases of 136 cases of retinoblastoma cases. Results of clinical features: (1) the age of onset more common in children under 3 years of age; (2) the majority of children failed to see when early vision loss; (3) the incidence of monocular more common. Pathological features: (1) more common in undifferentiated tumors; (2) optic nerve without metastasis more common. Conclusion Strengthen science popularization, advocate prenatal and postnatal care. For early detection, early local conservative treatment to preserve the patient’s eyes and partial vision.