目的 :探讨 P1 6 蛋白在子宫内膜癌发生中的作用及与细胞增殖的关系。方法 :采用免疫组化方法对 33例子宫内膜癌 P1 6 蛋白和增细胞核抗原 (PCNA)进行检测。结果 :P1 6 蛋白在子宫内膜癌的阳性率为 6 0 .6 % ,显著低于正常子宫内膜 (10 0 % ,P<0 .0 1) ,且随组织学分级增加而逐渐降低。 PCNA在子宫内膜癌中阳性率为 81.8%。结论 :P1 6蛋白与子宫内癌的发生发展相关 ,测定子宫内膜癌 P1 6 蛋白的表达有助于确定肿瘤的分化程度。 Objective: To investigate the role of P1 6 protein in the pathogenesis of endometrial carcinoma and its relationship with cell proliferation. Methods: Immunohistochemistry was used to detect the expression of P1 6 protein and PCNA in 33 cases of endometrial carcinoma. Results: The positive rate of P1 6 protein in endometrial carcinoma was 60.6%, which was significantly lower than that in normal endometrium (100%, P <0.01), and gradually decreased with the increase of histological grade. The positive rate of PCNA in endometrial carcinoma was 81.8%. Conclusion: P1 6 protein is associated with the occurrence and development of intrauterine cancer. The determination of P1 6 protein expression in endometrial cancer will help to determine the degree of tumor differentiation.