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本文研究了钙拮抗剂硫帕米(Tiapamil)的抗高血压作用以及它对人体代谢的影响。 20例轻至中度原发性高血压病人,卧位舒张压为12.7～15.3 kPa(体重超常者和有糖尿病、高血脂病史者除外)。试验先给予本品300mg一日2次,服药2周后,舒张压未降至12.7 kPa以下者日剂量逐渐增加至900～1200mg,服药6周后,受试者按各自的最佳剂量继续服用本品52周。试验中定期测量受试者的卧位、坐位血压和心率,并作生化检查。结果:受试者服药后血压下降,4
This article studies the antihypertensive effect of the calcium antagonist Tiapamil and its effect on human metabolism. 20 patients with mild to moderate essential hypertension, supine diastolic pressure was 12.7 ~ 15.3 kPa (except for those with overweight and diabetes, history of hyperlipidemia). Test to give this product 300mg twice a day, 2 weeks after taking the drug, diastolic blood pressure did not fall below 12.7 kPa daily dose gradually increased to 900 ~ 1200mg, 6 weeks after taking the subjects according to their optimal dose to continue taking This product is 52 weeks. Test subjects regularly measured supine, sitting blood pressure and heart rate, and for biochemical tests. Results: Subjects blood pressure after taking medication, 4