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目的：研究疟原虫抗青蒿酯钠的产生机理。方法：以异硫氰酸荧光素－伴刀豆球蛋白Ａ（Ｆ－ＣｏｎＡ）为探针，采用荧光显微分光光度技术，对伯氏疟原虫滋养体膜表面的ＣｏｎＡ结合位点结合量进行了测定。结果：抗青蒿酯钠滋养体膜表面的ＣｏｎＡ结合位点结合量明显低于其正常株。结论：抗青蒿酯钠原虫膜表面的糖类已发生了改变。而膜的流动性变化可能是ＣｏｎＡ结合位点结合量改变的原因之一。
Objective: To study the mechanism of malaria parasite production against artemisinin. Methods: Fluorescein isothiocyanate-concanavalin A (F-ConA) was used as a probe, and fluorescence microspectrophotometry was used to detect the ConA binding site on Plasmodium berghei membrane. Measured. RESULTS: The binding amount of ConA binding site on the surface of trophozoite membrane was significantly lower than that of the normal strain. Conclusion: The sugars on the surface of A. artemisinin membrane have changed. The change of the fluidity of the membrane may be one of the reasons for the change in the binding amount of the ConA binding site.