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目的 探讨凋亡抑制基因bcl—2、p53及ki—67在膀胱移行细胞癌(TCC)和腺性膀胱炎(CC)中的表达,及其与TCC分化和浸润程度的关系。方法 采用免疫组化Dako Envision System方法,测定bcl—2、p53、ki—67在72例TCC和47例CC中的表达情况。结果 Bcl—2、p53和ki—67在TCC中表达的阳性率分别为31.9％、65.3％和51.4％,在CC中表达的阳性率分别为89.4％、14.9％和10.6％;低分化TCC易于高表达p53和ki—67,ki—67高表达还与TCC浸润性显著相关。结论TCC的发生发展与bcl—2、p53基因调节失控有关,bcl—2表达可能是TCC肿瘤发生过程中的早期事件,p53和ki—67高表达是TCC分化程度低及浸润性强的标志。
Objective To investigate the expression of apoptosis-suppressing genes bcl-2, p53 and ki-67 in transitional cell carcinoma of bladder (TCC) and cystitis glandula (CC) and their relationship with the differentiation and infiltration of TCC. Methods Immunohistochemical Dako Envision System was used to determine the expression of bcl-2, p53 and ki-67 in 72 cases of TCC and 47 cases of CC. Results The positive rates of Bcl-2, p53 and ki-67 expression in TCC were 31.9%, 65.3% and 51.4%, respectively, and the positive rates in CC were 89.4%, 14.9% and 10.6% High expression of p53 and ki-67, ki-67 overexpression also significantly associated with TCC infiltration. Conclusions The occurrence and development of TCC are related to the uncontrolled regulation of bcl-2 and p53 genes. The expression of bcl-2 may be an early event in the tumorigenesis of TCC. The high expression of p53 and ki-67 is a marker of low differentiation and invasiveness of TCC.