论文部分内容阅读
目的:从中枢发热介质的角度探讨野黄芩甙的解热机制。方法:本实验用内毒素(ET)复制家兔发热模型,观察野黄芩甙的解热作用及对家兔下丘脑和脑脊液中环磷腺苷(cAMP)含量的影响。结果:静脉注射ET后80 min,野黄芩甙+ET组家兔的体温明显低于ET组(P<0.01),表明野黄芩甙具有明显的解热作用;并且野黄芩甙能抑制ET所致的下丘脑中cAMP含量的升高(P<0.01)和脑脊液中cAMP含量的升高(P<0.01);相关分析显示,下丘脑和脑脊液中cAMP的含量变化与体温变化之间呈明显的正相关(P<0.01)。结论:野黄芩甙可能是通过抑制下丘脑和脑脊液中cAMP含量升高而发挥其解热作用的。
Objective: To explore the antipyretic mechanism of Rhizoma Astragalus from the perspective of central heating medium. METHODS: In this experiment, endotoxin (ET) was used to replicate febrile rabbit models. The antipyretic effect of wild Astragalus membranaceus and effects of cyclophosphoryl adenosine (cAMP) content in hypothalamus and cerebrospinal fluid of rabbits were observed. RESULTS: At 80 min after intravenous injection of ET, the body temperature of rabbits in the wild type + ET group was significantly lower than that in the ET group (P<0.01), indicating that the wild jaundice has a significant antipyretic effect; and wild buckwheat can inhibit ET The increase in cAMP content in the hypothalamus (P<0.01) and cAMP content in the cerebrospinal fluid (P<0.01); correlation analysis showed a clear positive correlation between cAMP levels in the hypothalamus and cerebrospinal fluid and changes in body temperature. Correlation (P<0.01). Conclusion: Scutellariae may exert its antipyretic effect by inhibiting the elevation of cAMP content in hypothalamus and cerebrospinal fluid.