速尿对急性肾功能衰竭是否有益处尚有争论。本文报道6例钩体病导致急性肾功能衰竭患者使用大剂量速尿,每6小时静脉给予500mg,当血清肌酐值下降时剂量渐减,7～8天内停用。另选择同样疾病而且肾功能衰竭程度相当的8例患者为对照组。两组入院时血的尿素氮、血清肌酐和尿量具可比性,统计学分析无差异。血清肌酐两组均在5.0～7.5mg/100ml。 Furosemide is still controversial for the benefit of acute renal failure. This article reports 6 cases of leptospirosis led to acute renal failure in patients with high-dose furosemide, intravenous infusion of 500mg every 6 hours, when the serum creatinine decreased dose diminished, 7 to 8 days of withdrawal. Another 8 patients with the same disease and equivalent degree of renal failure were selected as the control group. The two groups of blood urea nitrogen, serum creatinine and urine volume comparable, no statistical difference. Serum creatinine in both groups were 5.0 ~ 7.5mg / 100ml.