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应用紫外分光光度法体外观察不同浓度的西米替丁及法莫替了对胃乙醇脱氢酶(ADH)活性的影响,结果表明:当西米替丁浓度为0.01mmol/L时,ADH活性明显下降,抑制率为44.9%(P<0.01),药物浓度越高,抑制作用越强.当西米替丁浓度达20mmol/L时,酶活性下降83.1%.而法莫替丁浓度达1mmol/L时才出现抑制作用,抑制率仅为14.3%(P<0.05).结果提示给予常规治疗剂量的西米替丁或法莫替丁时,前者对ADH有明显抑制作用,后者对ADH无明显影响.因此,需要应用H_2受体拮抗剂治疗的嗜酒者宜选用法莫替丁.
The effects of different concentrations of cimetidine and famotidine on the activity of gastric alcohol dehydrogenase (ADH) were observed by UV spectrophotometry in vitro. The results showed that when the concentration of cimetidine was 0.01mmol / L, ADH activity The inhibition rate was 44.9% (P <0.01), and the higher the drug concentration was, the stronger the inhibition was.When the concentration of cimetidine reached 20mmol / L, the enzyme activity decreased by 83.1% .The concentration of famotidine reached 1mmol / L, the inhibitory rate was only 14.3% (P <0.05) .The results suggest that the conventional treatment dose of cimetidine or famotidine, the former has a significant inhibitory effect on ADH, the latter on ADH No significant effect.Therefore, need to use H 2 receptor antagonist treatment of alcoholics should use famotidine.