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用~(125)I和甲状腺素处理NMRI雌性小鼠,观察肾上腺素α-受体激动剂和拮抗剂对小鼠甲状腺素分泌的影响。以Mckenzie氏法测定小鼠血中的放射性碘水平,反映甲状腺素分泌的情况。 α-受体激动剂去甲肾上腺素(NA)和α_1受体激动剂苯肾上腺素都可以增加小鼠血中的放射性碘。前者较后者的作用强。α_2受体激动剂可乐亭抑制基础的放射性碘水平。α受体抑制剂酚妥拉明和α_1受体拮抗剂哌唑嗪均可消除NA升高小鼠血中放射性碘的作用;α_2受体拮抗剂育亨宾在低剂量时
NMRI female mice were treated with ~ (125) I and thyroxine to observe the effects of adrenergic α-agonists and antagonists on thyroid hormone secretion in mice. The level of radioactive iodine in the blood of mice was measured by Mckenzie’s method to reflect the secretion of thyroxine. The alpha-receptor agonist norepinephrine (NA) and the alpha-1 receptor agonist phenylephrine both increase radioiodine in the blood of mice. The former is more effective than the latter. Inhibitors of basal radioactive iodine levels by the α_2 receptor agonist. α receptor antagonist phentolamine and α_1 receptor antagonist prazosin can eliminate the role of NA in raising blood iodine in mice; α 2 receptor antagonist yohimbine at low doses