论文部分内容阅读
目的探讨卡培他滨维持化疗治疗晚期胃癌和术后复发转移胃癌的效果。方法选取2013-03—2014-12期间在辽宁省丹东市第一医院完成6周化疗的胃癌患者50例,随机分为观察组与对照组,每组患者25例。对照组患者以5-氟尿嘧啶联合顺铂作为化疗方案。观察组在此基础上联合卡培他滨进行维持化疗。比较两组患者1、2年的生存率,并评价卡培他滨所产生的毒性反应及对其受累脏器所产生的影响。结果两组患者的1年生存率差异无统计学意义(P>0.05);观察组患者2年生存率明显高于对照组(P<0.05)。其中,观察组患者所呈现出的Ⅲ~Ⅳ度毒性反应为白细胞降低、手足综合征等。在受累脏器中,肝脏转移病灶表现出了较好的反应性。结论卡培他滨可维持诱导化疗后取得CR、PR、SD的无手术指征晚期胃癌的生存时间,提高患者的2年生存率。
Objective To investigate the effect of capecitabine in maintenance chemotherapy on advanced gastric cancer and recurrence and metastasis of gastric cancer. Methods Fifty patients with gastric cancer who completed 6 weeks of chemotherapy during the period of 2013-03-2014-12 in Dandong First Hospital of Liaoning Province were randomly divided into observation group and control group, with 25 patients in each group. Patients in the control group received 5-fluorouracil plus cisplatin as a chemotherapy regimen. On this basis, the observation group combined with capecitabine to maintain chemotherapy. The survival rates of one and two years were compared between the two groups, and the toxicity of capecitabine and the effects on the organ involved were evaluated. Results There was no significant difference in one-year survival rate between the two groups (P> 0.05). The 2-year survival rate in the observation group was significantly higher than that in the control group (P <0.05). Among them, the observed group of patients showed Ⅲ ~ Ⅳ toxicity of leukopenia, hand-foot syndrome and so on. In the affected organs, liver metastases showed better reactivity. Conclusion Capecitabine can maintain the survival time of advanced gastric cancer without surgery indications of CR, PR, SD after induction chemotherapy and improve the 2-year survival rate of patients.