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通过对86例原发性胆汁返流性胃炎空腹1h胃液三羟胆酸含量、游离酸测定，研究三羟胆酸与萎缩性胃炎（CAG）、胃癌癌前病变的关系。结果表明：CAG组三羟胆酸含量明显高于浅表性胃炎组（CSG）及对照组，尤以CAG伴结肠型肠化、不典型增生者含量最高，而游离酸值最低。胃粘膜活检见大量中性粒细胞浸润，以CAG组明显（55．2％）。提示胆汁酸浓度与胃粘膜炎症程度、性质密切相关，胆汁返流致胃酸过少继发细菌感染，是促使CAG、胃癌前病变发生的重要因素之一。胃游离酸检测与胃腺体受损程度不平行，但测定空腹胃游离酸对判断病情轻重及预后有临床实用价值。
The relationship between trihydroxycholic acid and atrophic gastritis (CAG) and precancerous lesions of gastric cancer were studied by measuring the contents of trihydroxycholic acid and free acid in gastric juice of 86 patients with primary biliary reflux gastritis for 1 hour. The results showed that the content of TCA in CAG group was significantly higher than that in superficial gastritis group (CSG) and control group, especially CAG with colonic intestinal metaplasia. The content of free acid was the highest in atypical hyperplasia. Gastric mucosal biopsy showed a large number of neutrophil infiltration, with CAG was significantly (55.2%). Tip bile acid concentration and gastric mucosal inflammation is closely related to the degree of nature, bile reflux caused by hypochlorhydria secondary bacterial infection is to promote CAG, one of the important factors in gastric precancerous lesions. Stomach free acid test and gastric gland damage is not parallel, but the determination of fasting gastric acid free to determine the severity and prognosis of clinical practical value.