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目的:观察淋巴细胞主动免疫联合黄体酮治疗不明原因复发性流产的临床疗效,探讨封闭抗体对妊娠结局的意义。方法:将81例确诊为不明原因复发性流产且封闭抗体阴性的患者随机分为两组,实验组45例采用淋巴细胞主动免疫联合黄体酮治疗,对照组36例采用传统保胎治疗(黄体酮+HCG)。比较封闭抗体在治疗前后的变化及受孕后的妊娠结局。结果:实验组妊娠成功率为73.33%,对照组为36.11%,差异有统计学意义(P<0.01)。结论:封闭抗体对妊娠结局有预示价值,淋巴细胞主动免疫联合黄体酮治疗不明原因复发性流产成功率较高,是治疗复发性流产的一种简单的好方法。
OBJECTIVE: To observe the clinical efficacy of active immune lymphocyte combined with progesterone in the treatment of unexplained recurrent spontaneous abortion, and to explore the significance of blocking antibodies in pregnancy outcome. Methods: Eighty-one patients with recurrent spontaneous abortion and closed antibody negative for unknown reasons were randomly divided into two groups. In the experimental group, 45 patients were treated with active immunization of lymphocytes combined with progesterone and 36 patients in the control group were treated with traditional tocolytic therapy + HCG). Compare the changes of closed antibody before and after treatment and the pregnancy outcome after conception. Results: The success rate of pregnancy in experimental group was 73.33% and in control group was 36.11%, the difference was statistically significant (P <0.01). Conclusion: Blocked antibodies have predictive value for pregnancy outcome. Active immunization with lymphocytes and progesterone in treatment of unexplained recurrent abortion have a high success rate, which is a simple and good method for the treatment of recurrent spontaneous abortion.