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青霉素PG是临床应用最普遍的抗生素,不良反应以变态反应最为严重.轻者仅发生红麻疹、寻麻疹、血管神经性水肿;中度者可见血清病型反应;重者则可发生立即危及生命的过敏性休克.我科收治一例PG致急性肾衰病人,现报告如下:女性患儿,5岁,藏族.住院号:921874.因咳嗽、发烧、纳差5天,院外曾肌注PG3天,效果不佳,于1992年10月7日以急住扁桃体炎(咽充血、扁桃体Ⅱ°,双颌下淋巴结肿大,有触痛)入我科.给予静滴PG160万/日.次日起尿量减少(<150ml/日).第4日起连续3天在输PG期间,面、躯干部出现尊麻疹,夜间隐退.尿减少后曾给试探性补液,利尿合剂等治疗,均无效.尿量减至<50ml/日.第7日面部、双下肢出现浮肿.查:血压正常,呼吸深长,咽部无充血,扁桃体Ⅰ°,颌下淋巴结不大,心肺(一),肝脾(一),腹水征(一).血嗜酸细胞绝对数450×10~6/L;尿常规:蛋白(++)、RBC(+)、
Penicillin PG is the most common clinical antibiotics, adverse reactions to the most severe allergy. Light only occurred in red measles, hives, angioedema; moderate disease can be seen in patients with serotypes; severe cases can occur immediately life-threatening Of anaphylactic shock.Our department treated a case of acute renal failure caused by PG, are as follows: Female children, 5 years old, Tibetan. Hospital number: 921874. Due to cough, fever, anorexia for 5 days, hospital had intramuscular PG3 days , The effect is not good, in October 7, 1992 with acute tonsillitis (pharyngeal congestion, tonsil Ⅱ °, submandibular lymph nodes, tenderness) into our department.Give intravenous PG160 million / day the next day Urine volume decreased (<150ml / day.) On the 4th day for 3 consecutive days during the PG, face, torso appear respectful measles, retreat at night.Decreased urine after giving tentative rehydration, diuretic mixture and other treatment, are Invalid. The urine output was reduced to <50ml / day. On the 7th day, there was edema on the face and lower extremities. Check: Normal blood pressure, long breathing, no throat congestion, tonsil Ⅰ °, submandibular lymph nodes, Spleen (a), ascites sign (a) .The absolute number of blood eosinophils 450 × 10 ~ 6 / L; urine: protein (++), RBC