论文部分内容阅读
目的 :探讨 Mu类谷胱甘肽转移酶基因 (GSTM1基因 )缺失多态与胃癌发病的相关性。方法 :采用聚合酶链反应 (PCR)方法 ,对 99例经手术及活检病理证实的胃癌患者进行 GSTM1基因检测 ,结合国人 GSTM1基因缺失统计学分布的标准对照进行病例对照研究。结果 :胃癌组 GSTM1基因缺失率为 6 3.6 % ,明显高于对照组缺失率 5 1.1% (P <0 .0 5 )。按吸烟分层分析表明 ,胃癌组大量吸烟者的 GSTM1基因缺失率增高趋势更明显 ,达6 7.5 % ,但此差异缺乏统计学显著性 (P >0 .0 5 )。结论 :GSTM1基因缺失多态与胃癌发病相关 ,该基因缺失可作为胃癌的宿主易感性标志之一。
Objective : To investigate the relationship between the deletion polymorphism of Mu glutathione transferase gene (GSTM1 gene) and the pathogenesis of gastric cancer. METHODS: Polymerase chain reaction (PCR) method was used to detect GSTM1 gene in 99 cases of gastric cancer patients confirmed by surgery and biopsy, and a case-control study was conducted in combination with the standard control of GSTM1 gene deletion in Chinese population. Results: The rate of GSTM1 gene deletion in gastric cancer was 63.6%, which was significantly higher than that of the control group (1.1%) (P < 0.05). According to stratified smoking analysis, the increase rate of GSTM1 gene deletion rate among the large number of smokers in gastric cancer group was more obvious, reaching 6 7.5 %, but this difference was not statistically significant (P > 0.05). Conclusion : The deletion polymorphism of GSTM1 gene is associated with the pathogenesis of gastric cancer. This gene deletion may be one of the host susceptibility markers of gastric cancer.