本文报告国内外首例由克柔氏念珠菌原发感染引起急性心内膜炎合并心包炎和室间隔穿孔致死亡的病例,首次证实了该真菌有较强的致病性.患者男,45岁,因不规则发热、进行性面色苍白48天,左眼失明30天,心前区疼痛伴活动后心悸气促8天入院。发病前未用过抗生素和免疫抑制剂,无慢性腹泻、口腔溃疡和心 This article reports the first case of death caused by acute endocarditis combined with pericarditis and ventricular septal perforation caused by the primary infection of Candida krusei at home and abroad, which for the first time confirmed the strong pathogenicity of the fungus. , Due to irregular fever, progressive pale 48 days, left eye blindness 30 days, precordial pain with activity palpitations breath 8 days admitted to hospital. Before the onset of antibiotics and immunosuppressive agents have not used, no chronic diarrhea, mouth ulcers and heart