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在神经生理学中最早导入抑制的概念,是在1845年由Weber 兄弟,电刺激迷走神经观察心跳减慢或停止的实验开始的。嗣后,于1862年,谢切诺夫用实验证明了刺激蛙脑可抑制其脊髓反射,从而提出了中枢抑制的概念。当时尚为医学生的巴甫洛夫,从谢切诺夫总结这一实验的著作“脑的反射”(1866)中得到很大启发,开始了唾液和胃液分泌的心理性影响的研究,并将其进一步发展成为条件反射学的体系。而在他的条件反射学中,一个重要的基本原理就是关于内抑制的概念。
The earliest introduction of inhibition in neurophysiology was started in 1845 by the Weber brothers, who electrically stimulated the vagus nerve to observe slowing or stopping of the heartbeat. Later, in 1862, Schechernoff experimentally demonstrated that stimulation of the frog brain inhibits spinal reflexes, leading to the concept of central suppression. When Pavlov, still a medical student, was greatly inspired by the book Stroke Reflex (1866), which Schnechern summed up in this experiment, he began a study of the psychological effects of saliva and gastric secretion To further develop it into a system of conditioned reflexology. In his reflexology, an important rationale is the notion of internal suppression.