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为了加速控制麻疹 ,了解麻疹疫苗 (MV)初始强化免疫的血清学效果 ,在 1997～ 1999年全省开展MV强化免疫活动期间 ,随机选择 11个县 (区、市 )设立强化免疫血清学监测点 ,对 1～ 6岁儿童在免疫前、后采集双份血清标本用血凝抑制 (HI)试验检测人群麻疹HI抗体。结果表明 :强化免疫后麻疹HI抗体阳性率由免疫前 92 96 %上升到 99 81%,抗体几何平均滴度倒数 (GMRT)由 18 11± 3 2 7上升到 44 77± 2 2 5 ,增长 2 4 7倍 ;强化免疫前各年龄组抗体阳性率为 89 16 %～ 97 37%,9～ 12岁GMRT最低 ,为 14 2 6± 2 6 4,强化免疫后各年龄组抗体阳性率为99 12 %～ 10 0 0 0 %,9～ 12岁GMRT上升到 39 0 8± 2 88;免疫后抗体有增长者占 6 8 83%,其中呈≥ 4倍增长者占 34 88%。通过强化免疫 ,大幅度提高群体的免疫水平 ,在相应的人群中已建立了牢固的免疫屏障 ,但是要重视MV的复种工作 ,预防麻疹爆发。
In order to speed up the control of measles and understand the serological effects of the initial boost of measles vaccine (MV), during the province’s intensive immunization campaign from 1997 to 1999, eleven counties (autonomous regions and municipalities) were randomly selected to set up surveillance stations for intensive immunization Two pairs of serum samples were collected before and after immunization for 1 ~ 6 years old children to detect HI antibody of measles with HI test. The results showed that the HI antibody positive rate of measles rose from 99.61% to 99.81% before immunization, and the geometric mean antibody reciprocal titer (GMRT) increased from 18 11 ± 37 to 44 77 ± 225, with an increase of 2 The positive rate of antibody in each age group before immunization was 89 16% -97 37%. The lowest GMRT rate was 14 2 6 ± 2 6 4 in patients aged 9-12 years. The positive rate of antibody in each age group after immunization was 99 12 The GMRT of 9-12 years old rose to 39 0 8 ± 2 88%. After immunization, the increase of antibody was 6 8 83%, of which 34 88% was ≥ 4 times increase. By strengthening the immune system and greatly improving the immunization level of the population, a solid immune barrier has been established in the corresponding population. However, it is necessary to pay attention to the multiple cropping work of MV to prevent the outbreak of measles.