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高迁移率族蛋白B1这一传统的非组DNA结合蛋白,与染色体的稳定性有关,并参与了细胞的转录等。近年研究发现,胞外高迁移率族蛋白1具有致炎细胞因子作用。胞内高迁移率族蛋白B1可通过活化细胞的主动分泌和坏死细胞的被动释放进入胞外,与细胞表面晚期糖基化终产物受体等配体结合后引发信号转导,诱导其他炎症介质的产生,扩大炎症反应。在动脉粥样硬化过程中,从炎症始发到斑块破裂及血栓形成的各个时期,高迁移率族蛋白B1均发挥重要的作用。
High mobility group protein B1, a traditional non-DNA binding protein, is involved in the stability of chromosomes and is involved in the transcription of cells. Recent studies have found that extracellular high mobility group protein 1 has pro-inflammatory cytokines. Intracellular high mobility group protein B1 can enter the extracellular space through active release of activated cells and passive release of necrotic cells. After binding to ligands such as advanced glycation end-products receptors on the cell surface, signal transduction is triggered to induce other inflammatory mediators Produce, expand the inflammatory response. In the process of atherosclerosis, high-mobility group protein B1 plays an important role in various stages of inflammation, including plaque rupture and thrombosis.