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[目的]探讨心理社会治疗对胃癌患者焦虑、抑郁情绪及免疫功能的影响。[方法]将100例胃癌患者随机分为试验组和对照组各50例,在常规治疗的基础上,试验组同时接受心理社会治疗。于入院、术后1个月、术后3个月时采用汉密顿焦虑(HAMA)及抑郁量表(HAMD)评定患者的焦虑、抑郁状况,采用流式细胞术测定T淋巴细胞亚群、NK细胞比率及散射浊光计免疫法测定血清补体和免疫球蛋白含量。[结果]两组患者在术后1个月时HAMA及HAMD评分均较入院时升高,而在术后3个月时则逐渐下降,与对照组相比,试验组患者的焦虑、抑郁状况明显较轻(P<0.05)。入院时试验组和对照组间T淋巴细胞亚群、NK细胞比率、血清补体和免疫球蛋白的差异无统计学意义(P>0.05),术后1个月、3个月时试验组中CD3+、CD4+、NK细胞、CD4+/CD8+比值、血清补体和免疫球蛋白均比对照组高,而CD8+细胞比对照组低。[结论]在胃癌患者中,焦虑、抑郁是较普遍的并发症状,采取有针对性的心理社会干预,可以改善患者心理状况,提高患者免疫功能。
[Objective] To investigate the effects of psychosocial therapy on anxiety, depression and immune function in patients with gastric cancer. [Methods] 100 gastric cancer patients were randomly divided into experimental group and control group of 50 cases, on the basis of routine treatment, the experimental group also received psychosocial treatment. HAMA and HAMD were used to evaluate the patients’ anxiety and depression status at admission, 1 month after surgery and 3 months after surgery. T lymphocyte subsets were determined by flow cytometry, NK cell ratio and scattering turbidimetric method were used to measure serum complement and immunoglobulin. [Results] The scores of HAMA and HAMD in both groups were higher than those at admission and gradually decreased at 3 months after operation at 1 month after operation. Compared with the control group, the scores of HAMA and HAMD in anxiety and depression Significantly lighter (P <0.05). There was no significant difference in T lymphocyte subsets, NK cell ratio, serum complement and immunoglobulin between the experimental group and the control group on admission (P> 0.05). The levels of CD3 + , CD4 +, NK cells, CD4 + / CD8 + ratio, serum complement and immunoglobulin than the control group, while CD8 + cells were lower than the control group. [Conclusion] In patients with gastric cancer, anxiety and depression are the more common complications. Psychological and social intervention can improve the patients’ psychological status and improve their immune function.