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目的探讨血胱抑素C、尿微量蛋白对窒息新生儿肾功能损害的诊断价值。方法选取新生儿窒息的新生儿80例为窒息组,按照新生儿窒息诊断标准又将其分为轻度组(45例)和窒息组(35例)。选取无肾功能损害的非窒息新生儿32例为对照组。用酶联免疫吸附法测定患儿日龄3d内的血尿素氮(BUN)、血肌酐(SCr)及血胱抑素(Cys C)尿微量蛋白α1微球蛋白(α1-M)、清蛋白(Alb)、β2微球蛋白(β2-M)的水平,比较各组间各指标的差异。结果窒息组血Cys C、SCr、BUN水平较对照组增高(P<0.05),尿α1-M、Alb、β2-M较对照组显著增高,重度组升高更明显(P<0.01)。结论用血Cys C和尿微量蛋白联合检测对临床肾功能的监测有重要意义。
Objective To investigate the diagnostic value of serum cystatin C and urinary microalbumin in renal dysfunction in asphyxia neonates. Methods Eighty newborn infants with asphyxia were selected as the asphyxia group, which were divided into mild group (n = 45) and asphyxia group (35) according to the diagnostic criteria of neonatal asphyxia. Thirty-two non-asphyxiated newborns without renal dysfunction were selected as the control group. Serum urea nitrogen (BUN), serum creatinine (SCr), and urine cystatin C (α1-M) and albumin in children were detected by enzyme-linked immunosorbent assay (Alb) and β2-microglobulin (β2-M) levels were compared between the various groups were compared. Results The levels of Cys C, SCr and BUN in the asphyxia group were significantly higher than those in the control group (P <0.05). Urine α1-M, Alb and β2-M levels in the asphyxia group were significantly higher than those in the control group and significantly higher in the severe group (P <0.01). Conclusion The combined detection of serum Cys C and urine microalbumin is of great significance for the monitoring of clinical renal function.