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近10年确定在克隆氏病时不仅胃肠道的各部分能发生损害,而且肝、胰和皮肤也能出现病理改变;但关于口腔粘膜损害还仅有个案报告。作者对32例克隆氏病进行了观察,结果30例发现了齿龈和口腔粘膜损害,现报告如下:作者对出现口腔改变的这30例克隆氏病患者除详细研究了整个病史和临床经过外,还对局部病变进行了内窥镜和组织学检查。25例是在出现胃肠道损害之前1.5～2年出现齿龈出血和瘙痒,其中8例口腔粘膜发生溃疡(也称溃疡性口炎);这些损害按齿龈疾病和口炎的治疗方法(防腐剂,抗菌剂)治疗无效。作者认为克隆氏病时口腔内出现的这些损害可能是进一步发生胃肠道损害的最初表现。5例是在出现胃肠道病变之后2～4年后发生齿龈和口腔粘膜损害,这些损害可能是全身病变进一步发展和播散的结果。30例病人的齿龈全都发生(氵弥)漫
Nearly 10 years to determine in Crohn's disease not only damage in various parts of the gastrointestinal tract, but also liver, pancreas and skin pathological changes; but there are only cases of oral mucosal damage reported. The author of 32 cases of Crohn's disease was observed, the results of 30 cases of gingival and oral mucosal damage were found, are reported as follows: The author of oral alterations in these 30 cases of Crohn's disease in addition to a detailed study of the entire history and clinical experience, Endoscopic and histological examinations were also performed on local lesions. 25 cases had gum bleeding and pruritus 1.5 to 2 years prior to gastrointestinal damage, 8 of which developed ulceration of the oral mucosa (also known as ulcerative stomatitis); these lesions were treated according to the treatment of gum disease and stomatitis (preservatives , Antibacterial agent) treatment is invalid. The authors conclude that these detrimental changes that occur in the mouth during Crohn's disease may be the first manifestation of further gastrointestinal damage. Five cases of gingival and oral mucosal damage 2-4 years after the onset of gastrointestinal lesions may be the result of further development and dissemination of systemic disease. 30 cases of patients with gums have occurred (Mi Mi) diffuse