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心脏毒性是限制长期使用阿霉素的主要因素,所以科学家一直在努力开发治疗指数更好、心脏毒性低的阿霉素类似物。许多人曾报道阿霉素在多种动物中诱发的心脏形态、生化和功能方面的变化,建议用这些模型来筛选新的类似物。但是已报道的方法有两个缺点:选择的动物种类不经济,如猴、狗、家兔等;蒽环类抗生素处理到心脏病理和动物死亡的出现间期太长。作者选用雌性Sprague-Dawley大鼠(体重150克)。每周静脉内注入阿霉素(3mg/
Cardiotoxicity is a major factor limiting the long-term use of doxorubicin, so scientists have been working hard to develop doxorubicin analogues with better therapeutic indices and lower cardiotoxicity. Many have reported changes in cardiac morphology, biochemistry, and function induced by doxorubicin in a variety of animals and suggested that these models be used to screen for new analogues. However, the reported method has two disadvantages: the animal species of choice is uneconomical, such as monkeys, dogs, rabbits and the like; the appearance of anthracycline to heart pathology and death of animals is too long. The authors selected female Sprague-Dawley rats (body weight 150 grams). Intravenous injection of doxorubicin (3 mg /