Typhoon is one of the most destructive natural calamities. Statistical data on 1949-1990 typhoons in China were used to analyze the frequency and strength of the typhoons, the relation between them and the average global ground temperature. The probability distribution of wind speed and the load of low buildings were obtained respectively on the basis of statistical data on the No. 9015 and No. 9711 typhoon. The finite element method and experimental comparison were used to obtained the probability distribution of lateral force resistance of a three story brick concrete building. Finally, the reliability indexes of this kind of building under No. 9015 and No. 9711 typhoon; and some valuable suggestions are given. Typhoon is one of the most destructive natural calamities. Statistical data on 1949-1990 typhoons in China were used to analyze the frequency and strength of the typhoons, the relation between them and the average global ground temperature. The probability distribution of wind speed and the load of low buildings were obtained respectively on the basis of statistical data on the No. 9015 and No. 9711 typhoon. The finite element method and experimental comparison were used to obtain the probability distribution of lateral force resistance of a three story brick concrete building. Finally, the reliability indexes of this kind of building under No. 9015 and No. 9711 typhoon; and some valuable valuations are given.