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目的探讨内脂素水平变化与多囊卵巢综合征之间的相互关系。方法选取2010年1月～2011年12月期间在某院检查确诊的128例多囊卵巢综合征患者(PCOS组),其中肥胖组52例及非肥胖组76例,随机选取门诊同期体检妇女120例作为对照组,观察各组体重指数(BMI)、腰臀比(WER)、血清卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、孕酮(P)、睾酮(T)、泌乳素(PRL)、内脂素、空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)变化情况。结果 PCOS组BMI、WER、LH、T、FINS、HOMA-IR水平高于对照组,PCOS组内脂素水平(32.27±16.62)ng/ml,对照组(18.83±12.21)ng/ml,两组之间比较差异有统计学意义(P﹤0.05);肥胖组患者BMI、FINS、HOMA-IR水平明显高于非肥胖组患者,肥胖组内脂素水平(34.86±17.14)ng/ml,非肥胖组(27.76±12.27)ng/ml,两组之间比较差异有统计学意义(P﹤0.05)。结论多囊卵巢综合征患者血浆内脂素水平较正常人群明显升高,并且在肥胖患者中升高更为明显。
Objective To investigate the relationship between changes in visfatin and polycystic ovary syndrome. Methods A total of 128 patients with PCOS diagnosed in a hospital from January 2010 to December 2011 were selected, including 52 obese patients and 76 non-obese patients, and randomly selected outpatients during the same period Cases were taken as control group. BMI, WER, FSH, LH, E2, P (T), prolactin (PRL), visfatin, fasting blood glucose (FPG), fasting insulin (FINS) and insulin resistance index (HOMA-IR) Results The levels of BMI, WER, LH, T, FINS and HOMA-IR in PCOS group were higher than those in control group. The levels of visfatin (32.27 ± 16.62) ng / ml in PCOS group and 18.83 ± 12.21 ng / ml in control group (P <0.05). The levels of BMI, FINS and HOMA-IR in obese patients were significantly higher than those in non-obese patients. The levels of visfatin (34.86 ± 17.14) ng / ml and obesity Group (27.76 ± 12.27) ng / ml, the difference between the two groups was statistically significant (P <0.05). Conclusions The level of plasma visfatin in patients with polycystic ovary syndrome is significantly higher than that of the normal population and is more obvious in obese patients.