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目的探讨ＩＬ－６和ＩＬ－８在监测胎膜早破中的作用。方法采用酶联免疫吸附实验对４６例胎膜早破孕妇母血清、羊水中ＩＬ－６和ＩＬ－８水平进行监测，并以正常足月妊娠孕妇２０例做对照组。结果胎膜早破孕妇母血清中ＩＬ－６、８和羊水中ＩＬ－６、８水平均较正常足月妊娠组高，差异显著（Ｐ＜０．０１；Ｐ＜０．０５）；随着破膜时间延长母血中ＩＬ－６、８和羊水中ＩＬ－６、８有增加趋势；绒毛羊膜炎患者１３例，其母血、羊水中ＩＬ－６和ＩＬ－８水平均明显高于非绒毛羊膜炎患者（Ｐ＜０．０５）。结论测定胎膜早破孕妇羊水ＩＬ－６和ＩＬ－８水平对识别绒毛羊膜炎起辅助诊断作用。
Objective To investigate the role of IL-6 and IL-8 in the monitoring of premature rupture of membranes. Methods The levels of IL-6 and IL-8 in maternal serum and amniotic fluid of 46 preterm premature rupture of membranes were detected by enzyme-linked immunosorbent assay (ELISA), and 20 pregnant women with normal term pregnancy were used as control group. Results The levels of IL-6,8 and IL-6,8 in amniotic fluid of pregnant women with premature rupture of membranes were significantly higher than those of normal pregnant women (P <0.01; P <0.05) The time of rupture of membrane was prolonged in IL-6,8 and amniotic fluid IL-6, 8, there was a trend of increase; in 13 cases of chorioamnionitis, the levels of IL-6 and IL-8 in maternal blood and amniotic fluid were significantly higher than those in non-amniotic fluid Chorioamnionitis patients (P <0.05). Conclusion The determination of amniotic fluid levels of IL-6 and IL-8 in pregnant women with premature rupture of membranes may play an auxiliary role in the identification of chorioamnionitis.