【摘 要】
：
Aplastic anemia is a kind of disease mainly manifested by bone marrow failure. Autophagy is very important for cells to adjust the changes and maintain the balance of themselves. Patients with AA suffer from defects in autophagy function, and the level of
【机 构】
：
Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Affiliated Hospital of Shando
论文部分内容阅读
Aplastic anemia is a kind of disease mainly manifested by bone marrow failure. Autophagy is very important for cells to adjust the changes and maintain the balance of themselves. Patients with AA suffer from defects in autophagy function, and the level of autophagy is closely related to the pathogenesis of AA. Autophagy may influence the proliferation and differentiation of HSC and their functional, hematopoietic microenvironmental and immune response, thereby mediating the occurrence and development of AA. This review will summarize the role o f HSC, hematopoietic microenvironment and immune response in the pathogenesis of AA, and further elaborated the application of autophagy in regulating T cell subsets and the autophagy function of Treg cells in the treatment of AA.
其他文献
Objective: To investigate the distribution characteristics of atypical pathogen infection in Hainan. Methods: A descriptive research was used to collect the data of 800 patients with atypical pathogen infection in Hainan, (including Burkholderia pseudomal
Objective: To systematically evaluate the effect of Xuesaitong injection combined with edaravone injection on hemorheology indexes in patients with acute cerebral infarction. Methods: Search CNKI, WanFang, VIP, SinoMed, PubMed, Cochrane Library and other
Insomnia is one of the most common clinical health problems, which can lead to a variety of complications and seriously affect human physical and mental health. Acupuncture has been used for treating insomnia for thousands of years, and is currently widel
Objective: To explore the synergistic mechanism of salvia miltiorrhiza and Pueraria lobata of multi-component, multi-target and multi-pathway in the treatment of type 2 diabetes mellitus (T2DM). Methods: The chemical components of Salvia miltiorrhiza and
[目的]探讨经皮肾镜钬激光碎石术后发生尿源性脓毒血症的患者外周血miR-223、miR-155-5p表达量及相关性.[方法]回顾性分析2015年5月至2020年6月本院收治的行经皮肾镜钬激光碎石术治疗的肾结石患者的临床资料,根据术后是否发生尿源性脓毒血症将其分为观察组(术后发生尿源性脓毒血症)和对照组(术后未发生尿源性脓毒血症),每组各52例.比较两组常规感染标志物降钙素原(PCT)、C反应蛋白(CRP)水平及miR-223、miR-155-5p表达量,分析经皮肾镜钬激光碎石术后尿源性脓毒血症影响因素,评
[目的]探讨巨噬细胞集落刺激因子(M-CSF)和β-连环素(β-Catenin)因子在重度子痫前期(pre-eelampsia,PE)患者血清中的表达及其临床意义.[方法]选择早发重度PE(早发重度PE组)、晚发重度PE患者(晚发重度PE组)各51例,比较两组患者血清M-CSF、β-Catenin细胞因子表达水平、临床生化指标及妊娠并发症发生率.[结果]早发重度PE组患者血清M-CSF、β-Catenin因子表达水平均显著高于晚发重度PE组,其差异有统计学意义(P ＜0.05);Pearson相关性分析显
[目的]探讨沉默间皮素(MSLN)基因对逆转卵巢癌顺铂(cDDP)耐药细胞株SKOV3/cDDP的影响.[方法]分别采用荧光定量PCR和Western blotting方法检测SKOV3/cDDP细胞及SKOV3细胞中MSLN mRNA和MSLN蛋白表达水平.分别用MSLN RNAi慢病毒液、空载体慢病毒液转染SKOV3/cD-DP细胞,建立稳定感染的细胞株SKOV3/cDDP-LV-MSLN-RNAi(实验组)和SKOV3/DDP-MSLN-neg(阴性组).分别应用MTT法和FCM检测转染后耐药细胞对
[目的]探讨C-反应蛋白(CRP)、可溶性白细胞分化抗原14亚型(sCD14-ST)、嗜中性粒细胞碱性磷酸酶(NAP)联合检测对小儿呼吸道感染性疾病的诊断价值.[方法]陕西省渭南市妇幼保健院儿科收治的50例呼吸道感染患儿为观察组,同期在本院健康体检小儿50例为对照组.比较两组血清CRP、sCD14-ST水平及NAP积分,比较病原菌不同的呼吸道感染患儿血清CRP、sCD14-ST水平及NAP积分;分析50例患儿CRP、sCD14-ST、NAP积分之间的相关性,比较CRP、sCD14-ST、NAP积分对呼吸道
[目的]探讨厦门地区未成年变应性鼻炎(Allergic Rhinitis,AR)的变应原分布特点.[方法]收集2016年1月至2019年12月在厦门大学附属第一医院耳鼻咽喉头颈外科门诊就诊的2639例临床可疑AR患者的皮肤点刺试验(Skin Prick Test,SPT)结果,分析变应原的分布特点.[结果]变应原阳性率由高到低分别为粉尘螨(68.62％)、屋尘螨(68.09％)、蟑螂(19.78％)、动物毛(1.89％)、杂草(0.42％)、霉菌Ⅰ(0.38％)、霉菌Ⅱ(0.19％)、芒果(0.08％).